Oxidation products of phenolic thiocolchicines: Ring a quinones and dienones

Article abstract of DOI:10.1080/00397919808006862

An improved, highly selective demethylation of thiocolchicine (1) to the diphenol 5 is described. Oxidation of 2 to para-quinone 6 and of 4 and 5 to ortho-quinones 8 and 10 is first reported. Also, 2-demethylthiocolchicine (3) was oxidized to the quinone methide 7.

Full text of DOI:10.1080/00397919808006862

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Oxidation Products of Phenolic
Thiocolchicines: Ring a
Quinones and Dienones
Jian Guan a , Arnold Brossi a , Xiao-Kang Zhu a , Hui-
Kang Wang a & Kuo-Hsiung Lee a
a Natural Products Laboratory, School of Pharmacy ,
University of North Carolina at Chapel Hill , Chapel
Hill, NC, 27599
Published online: 22 Aug 2006.
To cite this article: Jian Guan , Arnold Brossi , Xiao-Kang Zhu , Hui-Kang Wang
& Kuo-Hsiung Lee (1998) Oxidation Products of Phenolic Thiocolchicines: Ring
a Quinones and Dienones, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 28:9, 1585-1591, DOI:
10.1080/00397919808006862
To link to this article: http://dx.doi.org/10.1080/00397919808006862
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