Solid-phase Suzuki cross-coupling reactions using a phosphine ligand based on a phospha-adamantane framework

Article abstract of DOI:10.1016/j.tetlet.2004.05.110

The use of a catalyst system based on Pd₂dba₃· CHCl₃ and 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phospha- adamantane allows for Suzuki coupling aryl halides with an array of boronic acids on a solid-phase platform. The reactions can be carried out at room temperature with low palladium loadings in high yields.