Journal of labelled compounds and radiopharmaceuticals p. 1239 - 1252 (2002)
Update date:2022-08-03
Topics:
Zheng, Qi-Huang
Liu, Xuan
Fei, Xiangshu
Wang, Ji-Quan
Ohannesian, David W.
Erickson, Leonard C.
Stone, K. Lee
Martinez, Tanya D.
Miller, Kathy D.
Hutchins, Gary D.
Novel radiolabeled O6-benzylguanine derivatives, 2-amino-6-O-[11C]-[(methoxymethyl)benzyloxy]-9-benzyl purines ([11C]p-O6AMBP, 1a; [11C]m-O6-AMBP, 1b; [11C]o-O6-AMBP, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agents for the DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT). The appropriate precursors for radiolabeling were obtained in three steps from starting material 2-amino-6-chloropurine with moderate to excellent chemical yields. Tracers were prepared by O-[11C]methylation of hydroxymethyl precursors using [11C]methyl triflate. Pure target compounds were isolated by solid-phase extraction (SPE) purification procedure in 45-60% radiochemical yields (decay corrected to the end of bombardment), and a synthesis time of 20-25 min. Copyright
View MoreWuxi Morality Chemical Co., Ltd
Contact:
Address:B/7F, 321th WuYun Rd, Wanda Plaza, Wuxi City, 214174, China
Contact:0550-7041128 0550-7090578
Address:Wangdian Street,Xinjie Town
Nanjing Norris Pharm Technology Co., Ltd.
Contact:+86-13901585132
Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China
Zhejiang Chemline International Co., Ltd.
Contact:+86-571-88062298
Address:Hengdian Industry Area, Dongyang, Zhejiang, China
Jinan Boss Chemical Industry Co., Ltd.
website:http://www.chemboss.com.cn
Contact:+86-531-58591595
Address:No2.Hualong Road, Jinan, China
Doi:10.1021/jo501171c
(2014)Doi:10.1002/anie.201400557
(2014)Doi:10.1016/j.tetlet.2014.05.115
(2014)Doi:10.1007/s10593-014-1531-2
()Doi:10.3987/COM-14-12988
(2014)Doi:10.1007/s00044-017-1784-2
(2017)