Synthesis of novel heterocyclic compounds for antitumor and radioprotective activities

Article abstract of DOI:10.1080/10426509808545486

Some novel pyridothienoxazine (5); pyridothienopyrimidines (6), (8), (9), (14); pyridothienoimidazole (16); isothiazolopyridine (17), and pyridoisothiazolopyrimidines (18-20) were synthesized. The structural assignment of the prepared compounds were based on microanalytical and spectroscopic evidences. Some prepared compounds were tested in vitro for their antitumor and radioprotective activities. Compounds (7), (12), (17) and (19) showed significant activities against EAC cells, at a concentration of 250μg/ml; while the isothiazolopyridine (17) exhibited radioprotective activity.

Full text of DOI:10.1080/10426509808545486

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Phosphorus, Sulfur, and
Silicon and the Related
Elements
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Synthesis of Novel
Heterocyclic Compounds
for Antitumor and
Radioprotective Activities
M.-M. Ghorab, A.-Y. Hassan & O.-M. Nassar
a Department of Drug Radiation Research,
National Centre for Radiation Research and
Technology; Atomic Energy Authority, P.O.
Box. 29, Nasr City, Cairo, Egypt
b Chemistry Department, Faculty of
Science, Girl's Branch, Al-Azhar University,
Cairo, Egypt
c Chemistry Department, Faculty of
Science, Girl's Branch, Al-Azhar University,
Cairo, Egypt
Version of record first published: 17 Mar
2008.
To cite this article: M.-M. Ghorab, A.-Y. Hassan & O.-M. Nassar
(1998): Synthesis of Novel Heterocyclic Compounds for Antitumor and
Radioprotective Activities, Phosphorus, Sulfur, and Silicon and the Related
Elements, 134:1, 447-462
To link to this article: http://dx.doi.org/10.1080/10426509808545486

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