Bioorganic and Medicinal Chemistry Letters p. 4444 - 4449 (2006)
Update date:2022-08-03
Topics:
De La Rosa, Martha
Kim, Hong Woo
Gunic, Esmir
Jenket, Cheryl
Boyle, Uyen
Koh, Yung-hyo
Korboukh, Ilia
Allan, Matthew
Zhang, Weijian
Chen, Huanming
Xu, Wen
Nilar, Shahul
Yao, Nanhua
Hamatake, Robert
Lang, Stanley A.
Hong, Zhi
Zhang, Zhijun
Girardet, Jean-Luc
A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates. Several of these compounds exhibited potent antiviral activities against efavirenz- and nevirapine-resistant viruses, containing K103N and/or Y181C mutations or Y188L mutation. Triazoles were first synthesized from commercially available substituted phenylthiosemicarbazides, then from isothiocyanates, and later by condensing the desired substituted anilines with thiosemicarbazones.
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