Rhodium(III)-Catalyzed C-H Activation: A Cascade Approach for the Regioselective Synthesis of Fused Heterocyclic Lactone Scaffolds

Article abstract of DOI:10.1021/acs.joc.9b03266

A Rh(III)-catalyzed cascade C-H activation; regioselective [4 + 2] oxidative annulation; and lactonization of aromatic acids, anhydrides, and acrylic acid derivatives with 4-hydroxy-2-Alkynoates have been disclosed. This strategy leads to fused heterocyclic lactone scaffolds in a single step with moderate functional group tolerance and excellent site selectivity. Besides, in one step, an antipode of the cephalosol intermediate natural product that contains a tricyclic isocoumarin framework has been synthesized.

Full text of DOI:10.1021/acs.joc.9b03266

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Article
Rhodium(III)-Catalyzed C-H Activation: A Cascade Approach for the
Regioselective Synthesis of Fused Heterocyclic Lactone Scaffolds
Anil Kumar, and Kandikere Ramaiah Prabhu
J. Org. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.joc.9b03266 • Publication Date (Web): 29 Jan 2020
Downloaded from pubs.acs.org on January 29, 2020
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The Journal of Organic Chemistry
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The Journal of Organic Chemistry
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