Bioorganic and Medicinal Chemistry Letters p. 4947 - 4954 (2007)
Update date:2022-08-03
Topics:
Mastalerz, Harold
Chang, Ming
Chen, Ping
Fink, Brian E.
Gavai, Ashvinikumar
Han, Wen-Ching
Johnson, Walter
Langley, David
Lee, Francis Y.
Leavitt, Kenneth
Marathe, Punit
Norris, Derek
Oppenheimer, Simone
Sleczka, Bogdan
Tarrant, James
Tokarski, John S.
Vite, Gregory D.
Vyas, Dolatrai M.
Wong, Henry
Wong, Tai W.
Zhang, Hongjian
Zhang, Guifen
Pyrrolotriazine dual EGFR/HER2 kinase inhibitors with a 5-((4-aminopiperidin-1-yl)methyl) solubilizing group were found to be superior to analogs with previously reported C-5 solubilizing groups. New synthetic methodology was developed for the parallel sy
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