N-HETEROCYCLIC COMPOUNDS AS RADIOPROTECTORS II. DERIVATIVES OF PYRIDINE AND PYRIMIDINE CONTAINING THIOL PRECURSORS

Article abstract of DOI:10.1016/0223-5234(88)90001-3

Pyridine and 4-substituted pyrimidine derivatives incorporating a sulphur functional side-group were evaluated as potential radioprotective agents by screening tests in mice. 2-(2-Pyridyl)ethanethiol and its derivatives showed some radioprotective action when administered intraperitoneally, but all were inferior to 2-pyridinemethanethiol.They showed no protection when administered orally.Substitution of the pyridine ring by chlorine gave compounds which also showed inferior radioprotective properties to those demonstrated by 2-pyridinemethanethiol.Corresponding phsphorothioates also exhibited little activity.The pyrimidine derivatives showed protection of a low order.Keywords: pyridine derivatives/ pyrimidine derivatives/ thiol/ thiol precursor/ radioprotectors