The first asymmetric synthesis of the naturally occurring (+)-Kotanin and the assignment of its absolute configuration

Article abstract of DOI:10.1016/S0957-4166(97)00117-1

The first asymmetric synthesis of the naturally occurring (+)-Kotanin is described. The key steps involve the intramolecular oxidative coupling of the cyanocuprate intermediate and the Fries rearrangement. The absolute configuration of (+)-Kotanin was assigned as aS by CD spectroscopic method.