Diastereoselective synthesis of functionalized 2,4-diamino-3-hydroxyglutaric acid derivatives of potential biological interest from glycine derivatives

Article abstract of DOI:10.1016/S0040-4039(00)73935-9

Two out of the four possible diastereomers of C- and N-protected 2,4-diamino-3-hydroxyglutaric acid derivatives 6a-c were obtained with diastereomeric excesses of 9:1 to 1:1. The compound 6b was converted into two lactam derivatives of 2,4-di(N-methylamin