Potential inhibitors of L asparagine biosynthesis. 2. Chemistry and biological activity of β hydroxyaspartic acid and its derivatives

DOI: 10.1021/jm00238a006

Source and publish data:

Journal of Medicinal Chemistry p. 354 - 358 (1975)

Update date:2022-08-04

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Authors:

Mokotoff

Bagaglio

Parikh Parikh

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Article abstract of DOI:10.1021/jm00238a006

Several derivatives of erythro β hydroxy DL aspartic acid (1) were prepared as potential inhibitors of L asparagine synthetase (ASase) from rat Novikoff hepatoma. Benzylation of 1 gave the dibenzyl ester 2 which upon coupling with carbobenzoxyglycine affo

Full text of DOI:10.1021/jm00238a006

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