Cannabinoids. Synthesis and central nervous system activity of 8 substituted 10 hydroxy 5,5 dimethyl 5H [1]benzopyrano[4,3 c] pyridine and derivatives

DOI: 10.1021/jm00221a031

Source and publish data:

Journal of Medicinal Chemistry p. 1508 - 1511 (1977)

Update date:2022-08-05

Topics:

Authors:

Lee Lee

Michaels

Zaugg Zaugg

Dren Dren

Plotnikoff

Young Young

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Article abstract of DOI:10.1021/jm00221a031

8-(1,2-Dimethylheptyl)- and 8-[5-(4-fluorophenyl)-2-pentyl]-10-hydroxy- 5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridines (2a and 2b), their phenolic ester and ether derivatives, and their N-oxides were synthesized and evaluated in various CNS pharmacological tests in animals. 2a was found to be the most potent compound.

Full text of DOI:10.1021/jm00221a031

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