The synthesis of (±)-aminoglutethimide via vicarious nucleophilic aromatic substitution of hydrogen

DOI: 10.1016/S0040-4020(97)10436-7

Source and publish data:

Tetrahedron p. 2269 - 2274 (1998)

Update date:2022-07-30

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Authors:

Bushell, Simon M.

Crump, J. Paul

Lawrence, Nicholas J.

Pineau, Guillaume

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Article abstract of DOI:10.1016/S0040-4020(97)10436-7

The synthesis of aminoglutethimide via a one-pot coupling of nitrobenzene, ethyl 2-chlorobutyrate and 3-bromopropionitrile has been achieved via a process involving sequential vicarious nucleophilic aromatic substitution and alkylation.

Full text of DOI:10.1016/S0040-4020(97)10436-7

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