Steroids p. 271 - 286 (1989)
Update date:2022-09-26
Topics:
Datcheva, Violeta K.
Voishvillo, Natalia E.
Kamernitskii, Aleksei V.
Vlahov, Radoslav J.
Reshetova, Irina G.
9α-Hydroxylation of Δ5-3β-hydroxysteroids (of androstane, pregnane, 24-nor- and 21,24-bisnorcholane groups) was carried out by a Rhodococcus sp., isolated from a petroleum-containing soil sample.A large number of the investigated steroids was transformed into 9α-hydroxy-Δ4-3-ketones in satisfactory yields (50 - 90percent) at high initial concentrations of the substrates (0.5 - 5.0 g/L).The influence of some structural features of the steroid molecule on the progress and effectiveness of the microbial transformation was also shown.
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