Tetrahedron p. 2259 - 2271 (2003)
Update date:2022-08-05
Topics:
Murphy, Paul V.
O'Brien, Julie L.
Gorey-Feret, Lorraine J.
Smith III, Amos B.
The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-D-glucopyranoside and 6-deoxy-6-amino-β-D-mannopyranoside scaffolds has been achieved. The inhibitors had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.
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