Chemical and Pharmaceutical Bulletin p. 462 - 466 (1998)
Update date:2022-07-29
Topics:
Takikawa, Mami
Uno, Kiyoko
Ooi, Takashi
Kusumi, Takenori
Akera, Shusaku
Muramatsu, Morimitsu
Mega, Hirohiko
Horita, Chie
Polydora websterii, a harmful lugworm that has serious adverse effects on pearl oyster cultivation, was inhibited by a marine diterpene, crenulacetal C, isolated from the brown alga Dictyota dichotoma. Based on consideration of the activity-structure relationship, several synthetic compounds having an aromatic moiety with a hydroxyalkyl chain were prepared. Bioassay using larvae of Polydora websterii as well as pearl oysters (Pinctada fucata martians) suggested that 1-(2-ferrule)-1-nonanol was the most promising inhibitor.
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