Halogen-Substituted Allenyl Ketones through Ring Opening of Nonstrained Cycloalkanols

Article abstract of DOI:10.1021/acs.orglett.1c00452

An efficient synthesis of halogen-substituted allenyl ketones via Ag-catalyzed oxidative ring opening of allenyl cyclic alcohols under mild reaction conditions has been achieved. The reaction features a wide substrate scope and excellent regioselectivity. The synthetic potential of the products has been demonstrated by their conversion to stereodefined alkenes and heterocyclic compounds.