Journal of Organic Chemistry p. 3253 - 3258 (1980)
Update date:2022-09-26
Topics:
Paaren, Herbert E.
DeLuca, Hector F.
Schnoes, Heinrich K.
A direct synthesis of C(1) hydroxylated vitamin D analogues from the corresponding vitamin D precursors has been developed.Allylic oxidation of 3,5-cyclovitamin D derivatives, readily obtained from the buffered solvolysis of vitamin D tosylates, with selenium dioxide yields 1α-hydroxylated 3,5-cyclovitamin D compounds which are smoothly converted to the desired 1α-hydroxyvitamin D derivatives by acid-catalyzed cycloreversion.Application of this scheme to vitamin D3 (1a), 25-hydroxyvitamin D3 (1b), and vitamin D2 (1c) affords the 1α-hydroxy products in ca.20 percent overall yield.
View MoreShanggao Ruiya Fine Chemicals Co., Ltd
Contact:+86-795-2592103
Address:Xingguang Nanlu,Shanggao County Industry Park
Henan PURUI Pharmaceutical Co., Ltd.
website:http://www.puruipharm.com
Contact:17739583555
Address:Yezhuangqiao,Xihua town, Henan province
Contact:86-571-61063068
Address:LINAN
Yancheng Smiling Imp & Exp Co., Ltd.
Contact:+86-515-83173586
Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Taizhou Crene Biotechnology co.ltd
Contact:86-576-88813233 88205808
Address:Economic Developed Zone of Taizhou Zhejiang China
Doi:10.1016/0957-4166(94)80139-8
(1994)Doi:10.1002/chem.200204544
(2003)Doi:10.1021/acs.jafc.6b05580
(2017)Doi:10.1071/CH9752417
(1975)Doi:10.1021/ie50538a058
(1954)Doi:10.1021/jo034785d
(2003)