Archiv der Pharmazie p. 215 - 219 (1994)
Update date:2022-08-05
Topics:
Hendrix
Roets
Bervoets
Thomas
Pijcke
Busson
Janssen
Hoogmartens
The synthesis of some impurities of the cephalosporin antibiotics cefalexin and cefradine is described. These impurities which may be present in commercial samples are formed during the semi-synthetic preparation of these antibiotics or upon their degradation. The preparation of these compounds enables the validation of selective quantitative analytical methods, such as column liquid chromatography and thin layer chromatography.
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(2004)
