Heterocyclic Communications p. 129 - 134 (2003)
Update date:2022-08-03
Topics:
Sedlak, Milos
Drabina, Pavel
Hanusek, Jiri
Five substituted 2-benzoylamino-2-methyl-thiopropanamides have been prepared and their ring-closure reaction studied in basic and strongly acid media. In bases the ring closure takes place at the terminal nitrogen atom of thioamide group to give the corresponding 5,5-dimethyl-5-phenylimidazoline-4-thiones, while in strongly acid medium the reaction involves the sulphur atom to give the substituted 4,4-dimethyl-2-phenylthiazolin-5-ones. The 5,5-dimethyl-5-phenylimidazoline-4-thiones are stable in both acid and base media. The 4,4-dimethyl-2-phenylthiazolin-5-ones undergo hydrolysis to 2-methyl-2-thiobenzoylamino-propionic acids. The mechanism of ring closure in basic medium has been studied in detail: its rate-limiting step is the decomposition of tetrahedral intermediate.
View MoreHANGZHOU YUNUO CHEMICAL CO.,LTD
website:http://www.yunuochem.com
Contact:0571-83715115
Address:hangzhou
Contact:86 21 3772 9386
Address:Rm.1803,Starry Bldg.1,1505 Meijiabang Road,Shanghai 201620 China
Anyang Double Circle Auxiliary CO.,LTD
Contact:0086-134 6082 4403
Address:dongfeng road, anyang city, henan province,china
A.M FOOD CHEMICAL CO., LIMITED
Contact:86-531-87100375
Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China
website:http://www.simagchem.com
Contact:+86-592-2680277
Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China
Doi:10.1021/ja01120a506
(1953)Doi:10.1016/S0040-4020(01)88042-X
(1993)Doi:10.1021/jo900133g
(2009)Doi:10.1002/ardp.19352730505
(1935)Doi:10.1016/S0040-4039(03)00670-1
(2003)Doi:10.1002/ejoc.200200626
(2003)
