Heterocyclic Communications p. 129 - 134 (2003)
Update date:2022-08-03
Topics:
Sedlak, Milos
Drabina, Pavel
Hanusek, Jiri
Five substituted 2-benzoylamino-2-methyl-thiopropanamides have been prepared and their ring-closure reaction studied in basic and strongly acid media. In bases the ring closure takes place at the terminal nitrogen atom of thioamide group to give the corresponding 5,5-dimethyl-5-phenylimidazoline-4-thiones, while in strongly acid medium the reaction involves the sulphur atom to give the substituted 4,4-dimethyl-2-phenylthiazolin-5-ones. The 5,5-dimethyl-5-phenylimidazoline-4-thiones are stable in both acid and base media. The 4,4-dimethyl-2-phenylthiazolin-5-ones undergo hydrolysis to 2-methyl-2-thiobenzoylamino-propionic acids. The mechanism of ring closure in basic medium has been studied in detail: its rate-limiting step is the decomposition of tetrahedral intermediate.
View MoreContact:27-792-602929
Address:SIDNEY MUFAMADI STREET 009949 X44 0700 POLOKWANE,LIMPOPO
Taimai Sanluck Pharmaceutical Co.,Ltd
Contact:86-592-7662921
Address:8D,No.186,Huarong Road,Huli,Xiamen,China
Zhangjiagang Jianing Import & Export Co.,Ltd.
Contact:086-512-55379012 13913607595
Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China
NANCHANG QINZHI SCI&TEC.CO.,LTD(expird)
Contact:+86-13687004106
Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China
Shanghai PengMo Biotechnology Co.,Ltd
website:http://www.pengmobio.lookchem.com
Contact:86-13052359378
Address:No.218 Hai Qu Road.Shanghai.China
Doi:10.1021/ja01120a506
(1953)Doi:10.1016/S0040-4020(01)88042-X
(1993)Doi:10.1021/jo900133g
(2009)Doi:10.1002/ardp.19352730505
(1935)Doi:10.1016/S0040-4039(03)00670-1
(2003)Doi:10.1002/ejoc.200200626
(2003)
