Heterocyclic Communications p. 129 - 134 (2003)
Update date:2022-08-03
Topics:
Sedlak, Milos
Drabina, Pavel
Hanusek, Jiri
Five substituted 2-benzoylamino-2-methyl-thiopropanamides have been prepared and their ring-closure reaction studied in basic and strongly acid media. In bases the ring closure takes place at the terminal nitrogen atom of thioamide group to give the corresponding 5,5-dimethyl-5-phenylimidazoline-4-thiones, while in strongly acid medium the reaction involves the sulphur atom to give the substituted 4,4-dimethyl-2-phenylthiazolin-5-ones. The 5,5-dimethyl-5-phenylimidazoline-4-thiones are stable in both acid and base media. The 4,4-dimethyl-2-phenylthiazolin-5-ones undergo hydrolysis to 2-methyl-2-thiobenzoylamino-propionic acids. The mechanism of ring closure in basic medium has been studied in detail: its rate-limiting step is the decomposition of tetrahedral intermediate.
View MoreChangzhou Sunsheng Chem Co., Ltd
Contact:+1-(989)-854-0648
Address:No. 28 Yinshan Rd., Xixiashu Industrial Park
Suzhou Lixin Pharmaceutical Co., Ltd.
Contact:86-512-88169812
Address:21 Tangxi Road, Suzhou New District, Suzhou 215151
Contact:13357117572
Address:No.149 Shiji dadao Road.
KangZhiYuan Pharmaceutical Company Limited
Contact:(Sabrina)86-20-85273232
Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Liaoyang hengye Chemical Co., Ltd.
Contact:86-419-5850866
Address:North Old Xiaoxiao Road,Yantai District, Dengta, Liaoyang, Liaoning, China
Doi:10.1021/ja01120a506
(1953)Doi:10.1016/S0040-4020(01)88042-X
(1993)Doi:10.1021/jo900133g
(2009)Doi:10.1002/ardp.19352730505
(1935)Doi:10.1016/S0040-4039(03)00670-1
(2003)Doi:10.1002/ejoc.200200626
(2003)
