Synthesis and enzymic hydrolysis of oligoribonucleotides incorporating 3-deazaguanosine: The importance of the nitrogen-3 atom of single conserved guanosine residues on the catalytic activity of the hammerhead ribozyme

DOI: 10.1002/hlca.200390222

Source and publish data:

Helvetica Chimica Acta p. 2726 - 2740 (2003)

Update date:2022-08-04

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Authors:

Seela, Frank

Debelak, Harald

Andrews, Lori

Beigelman, Leonid

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Article abstract of DOI:10.1002/hlca.200390222

Four base-modified hammerhead ribozyme/substrate complexes were constructed in which single guanosine (1) residues were replaced by 3-deazaguanosine (2) in the positions G₅, G₈, G _L2.1, and G₁₂. The base-modifie

Full text of DOI:10.1002/hlca.200390222

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