Bioorganic and Medicinal Chemistry Letters p. 1527 - 1532 (1999)
Update date:2022-08-04
Topics:
Cathers, Brian E.
Schloss, John V.
We have developed a novel strategy for the preparation of tetrahedral transition state analogs for aspartic acid and metallo-proteases based upon the sulfonimidamide functional group. Our best α-des-amino dipeptide analog binds at least 100-fold tighter than the corresponding ground state structure (i.e., amide). A previously unpublished five-membered cyclic sulfonimidamide was also synthesized.
View MoreContact:86-516-66656369
Address:The west road of Huaihai, Xuzhou, China
Chengdu Gelipu Biotechnology Co., Ltd.
website:http://www.glp-china.com
Contact:86-28-82610909
Address:chegndu
website:http://www.oceanchem-group.com
Contact:86-536-8596048
Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
Angelisun(Chongqing) Pharmaceutical Co., LTD.
Contact:+86-23-68030926-816
Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
Neworld Chemical Co., Ltd Shanghai(expird)
Contact:+86-21-62202658
Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
Doi:10.1016/j.bmc.2004.06.019
(2004)Doi:10.1016/j.bmcl.2005.06.028
(2005)Doi:10.1016/S0040-4039(02)00134-X
(2002)Doi:10.1246/bcsj.34.1384
(1961)Doi:10.1021/jo0201023
(2002)Doi:10.1021/om050209r
(2005)
