Bioorganic and Medicinal Chemistry Letters p. 2307 - 2310 (2003)
Update date:2022-08-03
Topics:
Sorensen, Bryan K.
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Von Geldern, Thomas
Emery, Maurice
Wang, Jiahong
Hickman, Bach
Grynfarb, Marlena
Goos-Nilsson, Annika
Carroll, Sherry
A β-C-glucuronide conjugate of the glucocorticoid receptor antagonist, Mifepristone 1, was prepared which maintained binding affinity, had modest in vitro activity, and was metabolically more stable than the parent. Pharmacokinetic studies suggest that the conjugate is recognized by the liver like O-glucuronides and may undergo a portion of the enterohepatic recirculation loop.
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