Tetrahedron Asymmetry p. 1249 - 1252 (1995)
Update date:2022-09-26
Topics: Asymmetric synthesis Catalyst Enantioselectivity Nucleophilic substitution Diastereoselective Diels-Alder Reaction Desymmetrization Chiral compound 1,3-dioxolane Thalidomide
Robin, Sylvie
Zhu, Jiarong
Galons, Herve
Pham-Huy, Chuong
Claude, Jean Roger
et al.
Benzyloxyamine reacted with BOC-glutamic-α-phenyl ester in the presence of carbodiimide to give BOC-amino-N-benzyloxypiperidinedione.Deprotection of the amino group followed by phthaloylation led to N-benzyloxythalidomide which was then converted into thalidomide.
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Doi:10.3762/bjoc.16.55
(2020)Doi:10.1016/S0960-894X(03)00482-7
(2003)Doi:10.1016/S0040-4039(02)02091-9
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(2002)
