Synthesis of Macrocyclic Propargylic Alcohols by Ene-Type Cyclization of Unsaturated Acetylenic Aldehydes

DOI: 10.1021/jo00036a002

Source and publish data:

Journal of Organic Chemistry p. 2766 - 2768 (1992)

Update date:2022-09-26

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Authors:

Marshall, James A.

Andersen, Marc W.

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Article abstract of DOI:10.1021/jo00036a002

Ene type cyclizations of ynals 6, 21, and 30 can be effected by EtAlCl2 in CH2Cl2 at -78 deg C to afford 14- and 12-membered homoallylic propargylic alcohols in 66-89 percent yield.

Full text of DOI:10.1021/jo00036a002

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