Bioorganic and Medicinal Chemistry p. 6332 - 6344 (2017)
Update date:2022-09-26
Topics:
Tian, Junjun
Vandermosten, Leen
Peigneur, Steve
Moreels, Lien
Rozenski, Jef
Tytgat, Jan
Herdewijn, Piet
Van den Steen, Philippe E.
De Jonghe, Steven
Astemizole is a H1-antagonist endowed with antimalarial activity, but has hERG liabilities. Systematic structural modifications of astemizole led to the discovery of analogues that display very potent activity as inhibitors of the growth of the Plasmodium parasite, but show a decreased hERG inhibition, when compared to astemizole. These compounds can be used as starting point for the development of a new class of antimalarials.
View MoreShenzhen Sunrising Industry Co., ltd.
Contact:+86 755 86571158 / 86571159 / 86571160
Address:2108 ZHENYE INT. BUSINESS CENTER,NO.3101-90 QIANHAI RD, NANSHAN,SHENZHEN, CHINA
Shifang Taifeng New Flame Retardant Co., Ltd
Contact:02884721008
Address:tingjiang industrial park, hefeng town
Taizhou YOJOY Chemical Co., Ltd.
Contact:13857143241
Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China
Contact:86+21-56421993
Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
shanghai jiuling chemical co.,ltd.
Contact:+86-21-50387295
Address:Zaozhuang Road, Pudong, Shanghai City. China
Doi:10.1021/jo01066a005
(1961)Doi:10.1016/j.tet.2003.11.009
(2004)Doi:10.1021/jo00883a021
(1976)Doi:10.1016/S0040-4039(02)02779-X
(2003)Doi:10.1016/S0040-4039(03)01261-9
(2003)Doi:10.1002/ejoc.201300136
(2013)