A convenient synthesis of S-alkyl O-aryl thiophosphoric acid derivatives

Article abstract of DOI:10.1055/s-1991-26491

A new convenient synthesis of S-alkyl O-aryl thiophosphoric acid derivatives is reported. The chlorination of O-aryl O,O-dialkyl thiophosphates with phosphorus oxychloride proceeds with isomerization to give S-alkyl O-aryl thiophosphorochloridates, which react further with various nucleophiles in the presence of base to give the title compounds.