An improved and practical synthesis of 5,5-dimethyl-3-(2-propoxy)-4-(4-methanesulfonylphenyl)-2-(5H)-furanone (DFP - A selective inhibitor of cyclooxygenase-2)

DOI: 10.1016/j.tet.2003.08.021

Source and publish data:

Tetrahedron p. 7915 - 7920 (2003)

Update date:2022-08-03

Topics:

Authors:

Padakanti, Srinivas

Pal, Manojit

Yeleswarapu, Koteswar Rao

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.tet.2003.08.021

DFP, a highly selective and potent COX-2 inhibitor, has been synthesized by a modified approach. Three modifications of the existing method enabled us to prepare DFP in good quantity.

Full text of DOI:10.1016/j.tet.2003.08.021

Products guided by the article

Product name:3-isopropoxy-5,5-dimethyl-4-(4-methylsulfanylphenyl)-2,5-dihydro-2-furanone

Cas No:610785-95-0

R&D Labs maybe for 610785-95-0

ShenZhen InnoSyn Biotech Co.,Ltd

website:http://www.innosyns.com

Contact:+86-755-28351685

Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District
HANWAYS CHEMPHARM CO.,LIMITED

website:http://www.hanwayschem.com

Contact:+86-18502787239(whatsapp)

Address:18-1-802, Green Garden, Jianghan District, Wuhan 430023, China
shandong zhongke taidou chemical co.,ltd

Contact:86-531-88682301

Address:Jinan shandong Province CHina
Wuxi Highness Chemical Co.,Ltd

website:https://www.phtpharmatech.com/

Contact:86-510-81771080

Address:No58 East Xinguan Rd, Guanlin Town, Yixing City, Jiangsu China
Shanghai Yingrui Biopharma Co., Ltd

Contact:021-3358 8661*8003

Address:shanghai

Relevant to this article

Doi:10.1021/jo00427a019
(1977)
Di-tert-butylsilylene (DTBS) group-directed α-selective galactosylation unaffected by C-2 participating functionalities

Doi:10.1016/S0040-4039(03)01647-2
(2003)
Microwave-assisted solid-state synthesis and characterization of thiohydantoin derivatives

Doi:10.1081/SCC-200054778
(2005)
Amide derivatives of tantalum and a niobium-promoted ring opening of 3,5-lutidine

Doi:10.1016/S0020-1693(02)01308-7
(2003)
Evidence for Intramolecular C-H Bond Activation and the Formation of a "Tucked-In" Complex of Hexamethylbenzene at a Tantalum(III) Center

Doi:10.1021/ja00188a033
(1989)
Copper-Catalyzed Site-Selective Oxidative C?C Bond Cleavage of Simple Ketones for the Synthesis of Anilides and Paracetamol

Doi:10.1002/adsc.201801096
(2019)

Article Doi