Journal of Heterocyclic Chemistry p. 1113 - 1117 (1989)
Update date:2022-08-04
Topics:
Crooks
Deeks
DeSimone
A series of 5-benzoyl-5-phenyl- and 5-phenyl-5-phenylhydroxymethylhydantoins have been synthesized from the reaction of urea, N-monosubstituted ureas and sym-N,N-disubstituted ureas with phenyltriketone hydrate, via a pinacol-pinacolone-type rearrangement mechanism. The compounds were evaluated for anti-convulsant activity in mice.
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