Synthesis of 5-benzoyl-5-phenyl- and 5-phenylhydroxymethyl-5phenylhydantoins as potential anticonvulsants

Article abstract of DOI:10.1002/jhet.5570260439

A series of 5-benzoyl-5-phenyl- and 5-phenyl-5-phenylhydroxymethylhydantoins have been synthesized from the reaction of urea, N-monosubstituted ureas and sym-N,N-disubstituted ureas with phenyltriketone hydrate, via a pinacol-pinacolone-type rearrangement mechanism. The compounds were evaluated for anti-convulsant activity in mice.