Synthesis of 3-phenoxy-1,3-dihydro-1-isobenzofuranones by palladium-catalyzed carbonylative cyclization of 2- bromobenzaldehyde with phenols

Article abstract of DOI:10.1002/jhet.5570360446

2-Bromobenzaldehyde reacts with phenols in acetonitrile under carbon monoxide pressure in the presence of a catalytic amount of bis(triphenylphosphine)palladium(II) chloride to afford the corresponding 3-phenoxy-1,3-dihydro-1-isobenzofuranones in high yie