Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic agonist and antagonist activity

DOI: 10.1021/jm00393a017

Source and publish data:

Journal of Medicinal Chemistry p. 1779 - 1787 (1987)

Update date:2022-08-05

Topics:

Authors:

Natsuka Natsuka

Nakamura

Nishikawa

Negoro Negoro

Uno Uno

Nishimura

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Article abstract of DOI:10.1021/jm00393a017

Racemates and enantiomers of 1-substituted 4-[2-(3-hydroxyphenyl)-1-phenylethyl]piperazine derivatives (3-18) were synthesized, and their analgesic and other pharmacological activities and structure-activity relationships were investigated. The S-(+) enan

Full text of DOI:10.1021/jm00393a017

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