Journal of Medicinal Chemistry p. 88 - 93 (1981)
Update date:2022-08-05
Topics: Antibacterial activity Text format Experimental Chemical terms Enhancement 1-oxacephalosporins
Murakami, Kazuhisa
Takasuka, Mamoru
Motokawa, Kiyoshi
Yoshida, Tadashi
The effect of replacement of sulfur in the cephem nucleus by oxygen upon the β-lactamase stability, infrared carbonyl frequency of the β-lactam ring, and antibacterial activity was investigated.The replacement reduced the stability of β-lactam compounds t
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