High yield [125I]iodide-labeling of iodinated carboranes by palladium-catalyzed isotopic exchange

Article abstract of DOI:10.1016/S0022-328X(03)00344-9

We have recently shown the feasibility of palladium-catalyzed isotopic exchange between [¹²⁵I]iodide and 2-iodo-para-carborane. In this work we have modified the methodology and extended its application to a wider range of iodinated carboranes. Thus, by using Herrmann's catalyst in toluene at 100 °C, 2-I-p-, 3-I- o -, 9-I-o -, 9-I- m -carborane, 1-phenyl-3-I- o -carborane and 1,2-diphenyl-3-I-o -carborane have been radiolabeled with ¹²⁵ iodine in high to excellent yields.