Journal of Pharmaceutical Sciences p. 1158 - 1161 (1983)
Update date:2022-09-26
Topics:
Levy
Hall
Lee
Synthetic esters of the C-4 hydroxyl group of podophyllotoxin (I) were prepared. In addition, esters were synthesized using the diol system of tetrahydropyranyl podophyllol (XV), produced by reducing the lactone ring of tetrahydropyranyl podophyllotoxin with lithium aluminum hydride. Six compounds, the acrylate (IV), 3,3-dimethyl acrylate (V), phenoxyacetate (IX), and ethyl adipate (XI) and I as well as podophyllol (XIV) and tetrahydropyranyl podophyllol dimesylate (XVIII), showed significant activity when tested using the P-388 lymphocytic leukemia screen at 3 mg/kg/day. None of the esters showed higher activity than that shown by the parent molecule I when tested at the same dosage level.
View MoreNINGBO PANGS CHEM INT’L CO., LTD.
Contact:+86-0574-27666801
Address:Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China
Contact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
A.M FOOD CHEMICAL CO., LIMITED
Contact:86-531-87100375
Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China
Contact:86-571-61063068
Address:LINAN
Jiangsu Taihu New Materials Holding Co., Ltd
Contact:+86-519-86160108
Address:Xueyan Town, Changzhou City, Jiangsu Province, 213169, China
Doi:10.1021/ja01198a046
(1947)Doi:10.1021/jo00436a015
(1977)Doi:10.1021/acs.inorgchem.7b01504
(2017)Doi:10.1080/00397919408010581
(1994)Doi:10.1016/j.bmc.2007.05.026
(2007)Doi:10.1021/ja029514j
(2003)
