Angewandte
Chemie
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[17] In our hands formation of the B-O-C cyclophane followed by
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bicycle (S. Boisnard, Ph.D. Thesis, Universitꢀ Paris-Sud, 2001),
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by macrolactamization (refs. [6a,7b]).
[18] Due to the overlap of several key signals in the 1H NMR spectra
of RP-66453 (1) and 2 in DMSO, we performed NOE studies on
their derivatives 18 and 17, respectively.
Angew. Chem. Int. Ed. 2003, 42, 4238 –4241
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