AL ZOUBI ET AL.
11 of 12
TABLE 8 Screening of minimal inhibitory concentration for sample with Gram‐positive bacteria and Gram‐negative bacteria
Minimal Inhibitory Concentration, μg/mL
Gram‐Positive Bacteria
Gram‐Negative Bacteria
Compounds
BS
SA
ES
PA
HL
1000
1800
2000
1600
2000
2000
1200
1000
1300
2000
1800
2000
2000
2000
1200
1800
1400
2000
2000
2000
1600
900
[VOHL(SO4)
[NiLCl]
1200
1400
1600
2000
1500
1000
[CuLCl]
[PdLCl]
[PtLCl3]
[ReLCl3]Cl
Dilutions for MIC
No of tubes for MIC
1
2
3
4
5
6
7
8
9
10
Concennration of drug (μg/ml)
4000
2000
1000
500
250
125
62.5
31.25
15.625
7.812
Abbreviations: BS, Bacillus subtilis NCIM 2063; EC, Escherichia coli NCIM 2911; PA, Pseudomonas aeruginosa NCIM 2036; SA, Staphylococcus aureus NCIM 2079.
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4 | CONCLUSION
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J. Saudi Chem. Soc. 2016, 20, 487.
In this paper, we have explored the synthesis and coordina-
tion chemistry of some monomeric complexes obtained from
the reaction of the tridentate ligand L with some metal ions.
The mode of bonding and overall structure of the complexes
were determined through physicochemical and spectroscopic
methods. Complexes formation study via molar ratio has
been investigated, and results were consistent to those found
in the solid complexes with a ratio of (M:L) as (1:1). The
thermodynamic parameters, such as ΔE*, ΔH*, ΔS*, ΔG*,
and K are calculated from the TGA curve using Coats‐Red
fern method. Hyper Chem‐8 program was used to predict
structural geometries of compounds in the gas phase. The
heat of formation (ΔHf) and binding energy (ΔEb) at 298 K
for the A, free ligand, and its complexes were calculated by
PM3 method. The synthesized ligand and its metal com-
plexes were screened for their biological activity against
bacterial species, 2 Gram‐positive bacteria (B. subtilis and
S. aureus) and 2 Gram‐negative bacteria (E. coli and
P. aeruginosa).
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