Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against Flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus

DOI: 10.1021/jm030842j

Source and publish data:

Journal of Medicinal Chemistry p. 4149 - 4164 (2003)

Update date:2022-08-04

Topics:

Authors:

Zhang, Ning

Chen, Huan-Ming

Koch, Verena

Schmitz, Herbert

Liao, Ching-Len

Bretner, Maria

Bhadti, Vishweshwar S.

Fattom, Ali I.

Naso, Robert B.

Hosmane, Ramachandra S.

Borowski, Peter

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Article abstract of DOI:10.1021/jm030842j

A series of ring-expanded ("fat") heterocycles, nucleoside and nucleotide analogues (RENs) containing the imidazo[4,5-e][1,3]diazepine ring system (9, 14, 15, 18, 24-26, 28, 31, and 33) and imidazo[4,5-e][1,2,4]triazepine ring systems (30b, 30c, 32, and 3

Full text of DOI:10.1021/jm030842j

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