Tetrahedron p. 209 - 217 (1982)
Update date:2022-08-04
Topics:
Wijnberg, B. P.
Speckamp, W. N.
Oostveen, A. R. C.
Stereocontrolled NaBH4/H+-reduction of 3,4-cis-disubstituted N-alkenyl imides 1-5 leads to secondary hydroxylactams.Tertiary hydroxylactams are formed via addition of MeMgCl to imides 2 and 4.HCOOH-Cyclisation of the hydroxylactams affords polycyclic piperidines through stereoselective α-acyliminium ring closure.Concomitant synchronous and stepwise cyclisation pathways are operative in the anti-periplanar addition of tertiary α-acyliminium ions to Me substituted olefins 8c and 11c.
View MoreYingkou Sanzheng Organic Chemical Co. Ltd.
Contact:+86-417-3638818
Address:25 Gengxinli Village, Daqing Road, Yingkou, Liaoning, China
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Zhejiang Tianyu Pharmaceutical Co., Ltd.
Contact:+86-576-84177669, 89189665,89189688,84168770
Address:Jiangkou Development Zone, Huangyan, Taizhou City, Zhejiang
Chengdu Gelipu Biotechnology Co., Ltd.
website:http://www.glp-china.com
Contact:86-28-82610909
Address:chegndu
Contact:+86-371-86058576
Address:NO.32, Jingsan Road, Zhengzhou, China
Doi:10.1016/S0968-0896(03)00063-4
(2003)Doi:10.1023/A:1012357001662
(2001)Doi:10.1016/j.tet.2005.03.064
(2005)Doi:10.1039/b303618a
(2003)Doi:10.1016/S0957-4166(03)00247-7
(2003)Doi:10.1002/ejoc.200300218
(2003)
