Tetrahedron Letters p. 7541 - 7544 (1996)
Update date:2022-07-29
Topics:
Murakami, Masahiro
Hayashi, Minoru
Tamura, Noriyasu
Hoshino, Yujiro
Ito, Yoshihiko
The dehydration of a carboxylic acid and an amine to form an amide linkage was performed by the use of a new water-compatible dehydrating agent, 2,2-dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)-3-furanone (DPTF). The application of this new agent to the peptide bond formation is also described.
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