A simple route to syn α-amino-β-hydroxy-esters by C-2 regioselective opening of α,β-epoxy esters with metal halides

Article abstract of DOI:10.1016/0040-4020(95)00873-7

α,β-Epoxy esters are opened by NaX (X=I, Br) in a regio and stereoselective fashion to β-hydroxy-α-halo esters, which represent suitable precursors of syn α-amino-β-hydroxy esters and β-hydroxy esters.