Bioorganic and Medicinal Chemistry Letters p. 2233 - 2236 (1999)
Update date:2022-09-26
Kanyonyo, Martial
Govaerts, Sophie J.
Hermans, Emmanuel
Poupaert, Jacques H.
Lambert, Didier M.
Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.
View Moreshanghai Tauto Biotech Co., Ltd
website:http://www.tautobiotech.com/en/index.htm
Contact:+86-21-51320588 ext. 8025
Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA
Chengdu NoVi Biotechnology Co., Ltd.(expird)
Contact:13551243286/028-81458053
Address:NO.168-1-224 JULONG ROAD WUHOU DISTRICT, CHENGDU CITY,SICHUAN PROVINCE
Contact:86+21-56421993
Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
Henan Sinotech Import&Export Corporation
website:http://www.hasinotech.com
Contact:86-371-86181678
Address:No. 260, Dongming Road,Jinshui District
Suzhou Sibian Chemical Technology Co., Ltd
website:http://www.sibianpharm.com
Contact:+8618169181984,+8618013186906
Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
Doi:10.1021/acs.orglett.7b01617
(2017)Doi:10.1039/DT9770000578
()Doi:10.1021/ja01270a025
(1938)Doi:10.1021/jo00444a029
(1977)Doi:10.1016/j.tet.2005.06.041
(2005)Doi:10.1021/jm00176a003
(1980)
