Bioorganic and Medicinal Chemistry Letters p. 2233 - 2236 (1999)
Update date:2022-09-26
Kanyonyo, Martial
Govaerts, Sophie J.
Hermans, Emmanuel
Poupaert, Jacques H.
Lambert, Didier M.
Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.
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