31. Synthesis of a masked p-quinone methide β-lactam as an active metabolite of nocardicins

Article abstract of DOI:10.1002/hlca.19950780212

Nocardicin A analogues 30, 34, and 38 as well as the highly strained quinone methide 43 were synthesized. β-Lactam 34 was found biologically active against several Gram-negative microorganisms in vitro; pyridinium N-oxide derivative 38 possessed activity