Journal of Medicinal Chemistry p. 1388 - 1393 (1977)
Update date:2022-08-04
Topics:
Baggaley
Fears
Hindley
Morgan
Murrell
Thorne
A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats. Structure-activity relationships are discussed in terms of cholesterol-lowering activity together with effects on body weight gain and liver lipids. A number of the compounds inhibited cholesterol and free fatty acid biosynthesis from [1-14C]acetate in rat liver slices in vitro. Ethyl 4-benzyloxybenzoate, ethyl 4-benzyloxybenzoic acid, ethyl 4-p-bromobenzyloxybenzoate, and ethyl 4-o-methoxybenzyloxyphenyl acetate exhibited the most favorable spectrum of activity.
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Doi:10.1016/0040-4020(77)80091-4
(1977)Doi:10.1002/hlca.19770600520
(1977)Doi:10.1002/jccs.201900389
(2020)Doi:10.1016/S0040-4020(01)80303-3
(1993)Doi:10.1039/c0ob00093k
(2010)Doi:10.1021/ja01615a058
(1955)