Functionalized LNA (locked nucleic acid): High-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2′-amino-LNA monomers

Article abstract of DOI:10.1039/b307026c

A molecular dynamics (MD) simulation, synthesis and very efficient hybridization for a series of N-acylated and N-alkylated derivatives of 2′-amino-LNA are reported.