Synthesis and biological activity of 3-(N-substituted pyridinium-4-thiomethyl)-7α-formamido cephalosporins

Article abstract of DOI:10.7164/antibiotics.46.1279

The synthesis and antibacterial activity of a series of 3-(1-substituted pyridinium-4-thiomethyl)-7α-formamido cephalosporins is described. All the derivatives showed good potency and stability to bacterial β-lactamases. The antibacterial efficacy seen with the N-alkyl pyridinium substituents was enhanced by the introduction of a catecholic side chain at C-7 and by preparation of N-(substituted amino)pyridinium derivatives.