Chemical and Pharmaceutical Bulletin p. 1193 - 1198 (1991)
Update date:2022-08-03
Topics:
Fujita
Yoshikuni
Sotomatsu
Mori
Ozaki
Sempuku
Ogino
Kise
Enomoto
A series of N-phenyl-Δ8-dihydroabietamide analogs were prepared and tested for hypocholesterolemic activity. The effects of substituents of the phenyl moiety on the activities were quantitatively analyzed by using various substituent parameters. The activities were enhanced by the electron-donating effect of ortho and para substituents and the bulkiness of ortho substituents. A combination of 2,6-dimethylaniline with resin acids other than Δ8-dihydroabietic acid produced lower activities than N-(2,6-dimethylphenyl)-Δ8-dihydroabietamide, abietane-type carboxamides being somewhat stronger than pimarane-type carboxamides. The conversion of the carboxamide group to other groups resulted in more or less of a decrease in activity, giving evidence that the carboxamide group is important to hypocholesterolemic activity.
View MoreShanghai shibo Chemical Co., Ltd
Contact:+86-021-60753516
Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
Shijiazhuang Haitian Amino Acid Co., Ltd.
Contact:+86-311-88908111
Address:Shijiazhuang Hebei province,China
Jiangxi Sunway Chemical Co. Ltd.
Contact:86-794-5259909
Address:Zone C Industry Park Jinxi
Contact:+86 21 34123252
Address:14, 4580 Dushi, Shanghai, China
website:http://www.truewingroup.com
Contact:86-311-66699812
Address:NO.600 ZHONGSHAN EAST ROAD SHIJIAZHUANG
Doi:10.1021/jo00402a015
(1978)Doi:10.1039/c4ob01220h
(2014)Doi:10.1021/ja00346a073
(1983)Doi:10.1021/jo00402a024
(1978)Doi:10.1246/cl.1982.1061
(1982)Doi:10.1016/j.tet.2003.10.062
(2003)