Tetrahedron p. 12349 - 12360 (1999)
Update date:2022-07-29
Topics:
Nagarajan
Satish Kumar
Venkateswara Rao
A new, facile, mild and simple method for the synthesis of macrolides was achieved from ω- hydroxy acids using di-tertbutyl dicarbonate (Boc2O), a cheap and commercially available reagent. A wide range of substrates were tested and give good yield of lactones. The effect of various simple bases on the yield of the macrolactonisation reaction was also studied.
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