Synthesis of imidazole based p38 MAP (mitogen-activated protein) kinase inhibitors under buffered conditions

Article abstract of DOI:10.1021/op060042t

This article describes chemistry that was developed to give access to multigram quantities of imidazole 479754 and several related analogues for Eli Lilly's p38 MAPK program targeting therapies to address inflammation. The molecules of interest have an is