Synthesis of (+/-)-6β-Prostaglandin I1 and (+/-)-6β-Decarboxyprostaglandin I1

DOI: 10.1039/P19810001312

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 1312 - 1316 (1981)

Update date:2022-07-29

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Authors:

Finch, Mark A. W.

Roberts, Stanley M.

Newton, Roger F.

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Article abstract of DOI:10.1039/P19810001312

The known hydroxy-aldehyde (5) has been converted into 6β-decarboxyprostaglandin I₁ (19) and 6β-prostaglandin I₁ (3) by (i) reaction with an appropriate organometallic reagent, (ii) cyclisation via the intermediate formation of an iodonium ion, and (iii) hydrodeiodination and desilylation.

Full text of DOI:10.1039/P19810001312

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