Synthesis of 3-(3,5-dioxo-[1,2,4]-oxadiazolidin-2-yl)propylphosphonic acids

DOI: 10.3797/scipharm.aut-03-06

Source and publish data:

Scientia Pharmaceutica p. 39 - 49 (2003)

Update date:2022-07-29

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Authors:

Kurz, Thomas

Geffken, Detlef

Wackendorff, Claudia

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Article abstract of DOI:10.3797/scipharm.aut-03-06

Cyclic carbonylation of hydroxyureas 3 with 1,1′-carbonyldiimidazole gave 3-(3,5-dioxo-[1,2,4]oxadiazolidin-2yl)propylphosphonic acid diethyl esters 4 which were converted into the corresponding phosphonic acids 5 with bromotrimethylsilane.

Full text of DOI:10.3797/scipharm.aut-03-06

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